Molecular imaging is an established research tool to study disease and therapy. The IVIS® platform, featured in over 8000 peer-reviewed publications, remains a widely used multimodal imaging platform to longitudinally assess disease development, elucidate underlying molecular and cellular mechanisms and assess therapeutic efficacy. More recently, IVIS is seeing increasing adoption in exciting and emerging application areas.
The first part of this webcast is titled ‘Assessing mutation expression and optimising gene silencing and gene editing in the eye – Changing the Final Destination’. This session demonstrates how transgenic animals expressing luciferase can be an ideal tool for understanding ocular pathologies and treatment outcomes. Indeed, CRISPR Cas9 has revolutionized biomedical research as novel applications utilizing gene editing are being reported constantly.
The second part is titled ‘Optical imaging in neuroscience: How to visualize neuroinflammation from the brains of living animals?’ This session is devoted to understanding the pathology of brain injuries and chronic neurological disorders using 2D/3D imaging tools. This research has significant implications for the healthcare industry given that nearly a third of the US population suffers from neurological disorders.
In summary, this webcast will emphasize the benefits of transgenic models coupled with imaging, in preclinical trials and/or target validation studies.